Effects of maternal exposure to cow ́ s milk high or low in isoflavones on carcinogen - 1 induced mammary tumorigenesis among rat offspring 2 3
نویسندگان
چکیده
Department of Animal Health and Bioscience, Faculty of Agricultural Sciences, University of 6 Aarhus, Denmark, Institute of Biomedicine, Medical Faculty, University of Turku, Finland, 7 Lombardi Cancer Centre and Department of Oncology, Georgetown University, Washington, 8 DC, USA, Department of Health Risk Analysis & Toxicology, School for Nutrition, 9 Toxicology and Metabolism (NUTRIM), Maastricht University, The Netherlands. 10
منابع مشابه
Effects of maternal exposure to cow's milk high or low in isoflavones on carcinogen-induced mammary tumorigenesis among rat offspring.
We investigated whether maternal exposure during pregnancy to cow's milk containing endogenous estrogens and insulin-like growth factor 1 (IGF-1) and either high or low levels of isoflavones from dietary legumes (HIM and LIM, respectively) affected carcinogen-induced mammary carcinogenesis in female rat offspring. Pregnant Sprague-Dawley rats were given HIM, LIM, or tap water (control) from ges...
متن کاملInhibitory effects of Bifidobacterium-fermented soy milk on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinogenesis, with a partial contribution of its component isoflavones.
High consumption of soybean and soybean-related products is hypothesized to contribute to protection against breast cancer. Soybean is a rich source of genistein, a putative cancer chemopreventive agent. Fermented soy milk (FSM), which is made of soy milk fermented with the Bifidobacterium breve strain Yakult, contains larger amounts of the isoflavone aglycones genistein and daidzein than unfer...
متن کاملMaternal exposure to tamoxifen during pregnancy increases carcinogen-induced mammary tumorigenesis among female rat offspring.
Tamoxifen is under investigation as a potential chemopreventive agent in women of child-bearing age who are at an increased risk to develop breast cancer. However, because tamoxifen may act as an estrogen in the fetus and high fetal estrogenic activity, in turn, may increase subsequent breast cancer risk, we wanted to determine the effects of a maternal exposure to tamoxifen during pregnancy on...
متن کاملIncreased Risk of Mammary Carcinoma Development following Transplacental and Trans-Breast Milk Exposure to a Food-derived Carcinogen, 2-Amino-l-methyl-6- phenylimidazo[4,5-£]pyridine (PhIP), in Sprague-Dawley Rats1
Effects of transplacental and trans-breast milk exposure to a foodderived mammary and colon carcinogen, 2-amino-l-methyl-6-phenylimidazo[4,5-¿>]pyridine (PhIP), were investigated in rats. Female SpragueDawley rats were administered PhIP in the diet (100 ppm) for 4 weeks before mating with nontreated males and also during gestation and lac tation. As controls, additional females were maintained...
متن کاملIn utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis.
The linkage of nutrition and cancer prevention is an intriguing concept that is gaining widespread support. Here, we investigated the influence of developmental context on dietary protection against tumorigenesis initiated by the direct-acting carcinogen N-methyl-N-nitrosourea (NMU), and examined potential mechanisms underlying these effects. Rats were exposed only in utero or for lifetime to A...
متن کامل